0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Crow's 'Lateralization Hypothesis' for Schizophrenia-Reply

Timothy J. Crow, PhD, FRCP, FRCPsych; Christopher D. Frith, PHD; EVE C. Johnstone, MD, FRCP, FRCPsych; David G. C. Owens, MD, FRCP, FRCPsych; Gareth W Roberts, PhD; Nigel Colter, BSc; Joanna Ball, MD, MRCP; Steven R. Bloom, MD, FRCP; Rosemary Brown; Clive J. Bruton, MD
Arch Gen Psychiatry. 1991;48(1):86-87. doi:10.1001/archpsyc.1991.01810250088014.
Text Size: A A A
Published online

We are grateful to Weinberger and colleagues for responding to our prediction1 that diagnosis-byside interactions with respect to brain structure should be detected in MRI studies of monozygotic twins discordant for schizophrenia. The findings they report fail to fulfill this prediction.

In that the laterality comparisons relate to anatomic differences that Weinberger et al have already identified between schizophrenic and well twins, we agree that the observations are relevant to our contention that disturbances in lateralization are at the heart of the disease process in schizophrenia. However we doubt that the findings abstracted from this study provide a definitive answer to this question for the following reasons.

None of the comparisons relates to temporal horn size, the measure that proved to be the most effective discriminator between patients with schizophrenia and normal subjects in our own study.

In a number of studies, ventricular enlargement has been reported to

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();