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Neurologic Soft Signs in Obsessive-Compulsive Disorder-Reply

Eric Hollander, MD; Concetta M. DeCaria, MS; Jihad B. Saoud, MS; Donald F. Klein, MD; Michael R. Liebowitz, MD
Arch Gen Psychiatry. 1991;48(3):278-279. doi:10.1001/archpsyc.1991.01810270090014.
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In Reply.—  The study by Bihari and coworkers represents an important replication and extension of our earlier report in the Archives. The authors correctly note that our initial findings are preliminary and require replication and that further comparisons with other psychiatric control groups are needed in particular to establish the specificity of this finding.Bihari et al found significantly more errors and involuntary movements in patients with OCD than in normal controls. While patients with other anxiety and SADS were intermediate on these measures, they scored significantly lower than patients with OCD. Drug-free patients with OCD did not significantly differ from patients with OCD who were treated for at least 8 weeks with serotonin reuptake blocker medication. The authors suggest that while medication may improve OCD symptoms, it does not appear to affect neurologic soft signs.The authors acknowledge that their results must be interpreted with caution in light of the small


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