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Ethanollike Properties of the Serotonergic Partial Agonist m-Chlorophenylpiperazine in Chronic Alcoholic Patients

Chawki Benkelfat, MD; David T. George, MD; David Nutt, MD, PhD; Dennis L. Murphy, MD; James L. Hill, PhD; Markku Linnoila, MD, PhD
Arch Gen Psychiatry. 1991;48(4):383. doi:10.1001/archpsyc.1991.01810280099018.
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To the Editor.—  Alcoholic patients have lower levels of 5-hydroxyindoleacetic acid in cerebrospinal fluid1; decreased availability of the serotonin precursor, tryptophan2; and reduced serotonin concentrations in platelets.3 These findings have led to the hypothesis that a dysregulation in serotonin metabolism may be involved in the pathogenesis of alcoholism. To further explore this hypothesis, we studied alcoholic patients who abstained from alcohol. Behavioral, physiological, and endocrine responses to the metabolite of trazodone hydrochloride, meta-chlorophenylpiperazine (m-CPP) hydrochloride, were used as indexes of serotonin receptor function in alcoholic patients.4Twenty-one male patients who fulfilled DSM-III-R criteria for alcohol dependence and Research Diagnostic Criteria for alcoholism were selected for the study. They were in good physical health, euthymic, and abstinent from alcohol for at least 3 weeks when the study began. After written, informed consent was obtained, normal saline solution (the placebo) was administered intravenously. Thirty minutes later, m-CPP (0.08


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