We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Bipolar Pedigrees

George Winokur, MD; Raymond Crowe, MD
Arch Gen Psychiatry. 1991;48(7):671. doi:10.1001/archpsyc.1991.01810310089022.
Text Size: A A A
Published online


To the Editor.—  In the April 1990 issue of the Archives,1 Berrettini et al analyzed nine bipolar pedigrees for linkage to three DNA loci in the Xq28 region and excluded a gene for bipolar illness from 30 centimorgans of that region. One explanation of nonreplication of X-chromosome linkage findings is genetic heterogeneity, as noted by Berrettini et al. Therefore, it is important to exclude pedigrees exhibiting father-son transmission, since they are inconsistent with X linkage. Pedigree 0048 in the study by Berrettini et al included two affected sons, one with bipolar illness and the other with cyclothymic personality disorder, connected to the pedigree by an unaffected father. The pedigree was included on the grounds that the illness in the sons could have come from their mother. However, no mention was made of affective disorder in the mother or her family. Therefore, while the authors' statement that nowhere in


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.