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Altered Modulation of Prefrontal and Subcortical Brain Activity in Newly Diagnosed Schizophrenia and Schizophreniform Disorder A Regional Cerebral Blood Flow Study

Pia Rubin, MD; Søren Holm, PhD; Lars Friberg, MD; Poul Videbech, MD; Henrik Steen Andersen, MD; Birgitte Bjerg Bendsen, MD; Nils Strømsø, MD; Jens Knud Larsen, MD; Niels A. Lassen, PhD; Ralf Hemmingsen, PhD
Arch Gen Psychiatry. 1991;48(11):987-995. doi:10.1001/archpsyc.1991.01810350027004.
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• To measure prefrontal and subcortical activity during a cognitive task, we examined 19 newly diagnosed schizophrenics and patients with schizophreniform psychosis. Seven healthy volunteers served as controls. The patients were drug naive or had received neuroleptics for a few days only. Cerebral blood flow distribution was depicted by single photon emission computed tomography at rest and during activation with the Wisconsin Card Sorting Test. A significant relative activation deficit in the left inferiorprefrontal region was revealed during the Wisconsin Card Sorting Test in the patient group. Furthermore, the patients had impaired striatal suppression on the left side during the cognitive task. The test performance was significantly impaired in the patients. The inability to reduce striatal activity may be due to a lack of corticostriatal feedback during prefrontal activation.


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