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Subjective Conclusions About Schizophrenia-Reply

Arch Gen Psychiatry. 1992;49(1):75-76. doi:10.1001/archpsyc.1992.01820010075011.
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In Reply.—  The response of Puryear et al to the research reports by us1 and by Breier et al2 focuses on an important issue regarding outcome in schizophrenia. How does one interpret the data on outcome in schizophrenia? Is a pessimistic or an optimistic view warranted?As we have suggested, in viewing outcome in schizophrenia, the eye of the beholder is important, and from which standpoint one views data on schizophrenia is crucial.1 On the one hand, one can adopt as a standpoint the older clinical expectations of a progressive downhill disorder. If this pessimistic viewpoint is adopted, the outcome results of schizophrenia in our article would be hopeful or optimistic. Thus, very few schizophrenic patients from the Chicago Follow-up Study (our sample of patients) have experienced a progressive downhill course, although approximately half showed uniformly poor outcome, and an additional 30% have showed moderate to severe impairment in


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