We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Current Excitement With D2 Dopamine Receptor Gene Alleles in Substance Abuse

George R. Uhl, MD, PHD; Antonio M. Persico, MD; Stevens S. Smith, PhD
Arch Gen Psychiatry. 1992;49(2):157-160. doi:10.1001/archpsyc.1992.01820020068010.
Text Size: A A A
Published online


Is there a D2 dopamine receptor (DRD2) alíele that predisposes to substance abuse? Following the report by Blum and colleagues1 of an association between the Alalíele of the DRD2 gene and alcoholism, a number of laboratories have attempted to replicate and extend studies of this association in substance abusing and control populations.2"6 On September 19 and 20, 1991, the National Institute on Drug Abuse held a conference in Baltimore, Md, entitled "D2 Receptor Alíeles in Substance Abuse: Have We Identified a Relevant Gene?" Workers from laboratories involved in this exciting research area were invited to present their methods and data, assess current knowledge, and discuss future directions. We summarize the findings, interpretations, and recommendations for improving the heuristic potential of future studies on the role of DRD2 gene variants in substanceabuse.

GENETIC CONTRIBUTIONS TO INTERINDIVIDUAL DIFFERENCES IN SUBSTANCE ABUSE VULNERABILITY  Individuals differ in their susceptibility to substance abuse. These interindividual differences in vulnerability to alcohol and drugs appear to arise from both genetic and environmental sources. Adoption studies indicate increased frequency of alcoholism and drug abuse among


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.