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Infants at Risk for Schizophrenia: Sequelae of a Genetic Neurointegrative Defect:  A Review and Replication Analysis of Pandysmaturation in the Jerusalem Infant Development Study

Barbara Fish, MD; Joseph Marcus, MD; Sydney L. Hans, PhD; Judith G. Auerbach, PhD; Sondra Perdue, DrPH
Arch Gen Psychiatry. 1992;49(3):221-235. doi:10.1001/archpsyc.1992.01820030053007.
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• A 1975 report stated that a schizophrenic genotype may be manifested in infants by a neurointegrative defect called pandysmaturation. Recent evidence supports this: (1) 12 studies found delayed development in schizophrenics' infants and in preschizophrenics; (2) "blind" psychometric evaluations favored an adult schizotypal disorder in four to six of seven high-risk subjects with pandysmaturation in the New York study; and (3) finally, in a partial replication of this method using the Jerusalem data, blind diagnoses of "probable" and "possible" pandysmaturation were significantly related to a parental diagnosis of schizophrenia and to cognitive and motor neurointegrative deficits at 10 years. Obstetrical complications were unrelated to diagnosis, pandysmaturation, or outcome in the overall sample. However, we found a small subgroup of schizophrenic offspring in whom the most severe motor deficits at follow-up were related to obstetrical complications, pandysmaturation, and low birth weight.

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