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Negative Symptoms Are Related to Both Frontal and Nonfrontal Neuropsychological Measures in Chronic Schizophrenia

Deborah Perlick, PhD; Steven Mattis, PhD; Peter Stastny, MD; Brett Silverstein, PhD
Arch Gen Psychiatry. 1992;49(3):245-246. doi:10.1001/archpsyc.1992.01820030077010.
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To the Editor.—  Breier et al1 recently reported results from a study of schizophrenia outcome demonstrating that cognitive measures of frontal lobe function obtained at follow-up were significantly related to outcome levels of negative symptoms on the Scale for the Assessment of Negative Symptoms (SANS), but not to positive symptoms assessed by the Brief Psychiatric Rating Scale (BPRS), noting the need to replicate these findings incorporating nonfrontal tasks. We report data assessing the association between symptom typology and frontal vs nonfrontal measures from a study of cognition, symptoms, and neuroleptics in chronic schizophrenia.

Subjects and Methods. —  Subjects were 28 male and 24 female Research Diagnostic Criteria—diagnosed chronic schizophrenic patients drawn from an urban state hospital and two of its outpatient clinics. Subjects ranged in age from 25 to 55 years (mean age, 39.1 years) and had a 5-year or longer duration of illness; their conditions were maintained with


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