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Phosphomonoesters and Phosphodiesters in the Brains of Schizophrenic Patients-Reply

Peter Williamson, MD; Dick Drost, PhD; Jeff A. Stanley, MSc; Thomas Carr, MD; Jane Rylett, PhD; Sandra Morrison, PhD; Harold Merskey, DM
Arch Gen Psychiatry. 1992;49(5):416-417. doi:10.1001/archpsyc.1992.01820050080016.
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In Reply. —  Brown provides an in- teresting explanation for our finding of normal PDE levels in chronic schizophrenic patients.1 In view of this, we have reexamined our data with regard to subtypes. Of the original 10 subjects, five were classified as paranoid, two as undifferentiated, and three as residual. The mean (±SD) PDE in the paranoid patients (36.8±0.7 mol %) was the same as that in the whole patient group (36.8±1.5 mol %), which suggests that subtypes are unlikely to account for our PDE findings.We believe that the most reasonable explanation for the difference between our study and that of Pettegrew et al2 is the stage of illness or the effects of medication. We have now had a chance to examine three firstepisode cases (mean age, 23.3±4.9 years).3 All met DSM-III-R criteria with the exception of two who have yet to meet the 6-month duration criterion. Two

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