We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

In Vivo Occupancy of Dopamine Receptors by Antipsychotic Drugs

Herbert Y. Meltzer, MD; Craig A. Stockmeier, PhD
Arch Gen Psychiatry. 1992;49(7):588-589. doi:10.1001/archpsyc.1992.01820070082019.
Text Size: A A A
Published online


To the Editor. —  Clozapine hydrochloride, an atypical antipsychotic drug, has been reported to occupy fewer striatal D2 dopamine receptors (DRD2) (38% to 63%) than typical neuroleptic drugs (>70%), as determined by positron emission tomography (PET) using raclopride labeled with carbon 11.1-3 Furthermore, clozapine has been shown by PET studies using 11CSchering 23390 as ligand to occupy more D1 dopamine receptors (DRD1) than typical neuroleptics.2,3See also p 538.Decreased DRD2 and increased DRD1 occupancy has been suggested as the explanation of why clozapine does not produce extrapyramidal symptoms in humans.3 We have offered an alternative theory, namely, that clozapine produces fewer extrapyramidal symptoms because of its higher serotonin2 (5-HT2) receptor-blocking properties compared with its DRD2-blocking properties.4 We have also suggested that the latter mechanism is relevant to the antipsychotic advantages of clozapine.5 Others5,6 have suggested that the


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.