November 1992, Vol 49, No. 11 >

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Article | November 1992

Geographic Variations in the Prevalence of Schizophrenia-Reply

John L. Waddington, PhD, DSc; Hanafy A. Youssef, MRCPsych; Anthony Kinsella, MSc, FIS

Arch Gen Psychiatry. 1992;49(11):907-908. doi:10.1001/archpsyc.1992.01820110071014.

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In Reply.— Few areas of epidemiologic research are so liable to provoke controversy as that of putative disease clustering; as espoused in a recent editorial, "Disease clusters provide for passion, amusement and despair."1 Protagonists usually fall into one of two camps: that of the proponent, or that of the "cluster buster"1,2; we note that Lin and Goodman adopt the eclectic position of seeking both to "bust" our Irish cluster and to champion their own cluster of Ashkenazi Jews. Their comments raise a number of technical, theoretical, and conceptual points for discussion.Lin and Goodman do not question our basic finding³ that the overall variation in prevalence rates for schizophrenia over 36 contiguous District Electoral Divisions, constituting one half of a rural Irish county, deviates significantly from a homogeneous Poisson process model for random occurrences in space. If this model is a reasonable approximation, there should be no trend

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Waddington JL, Youssef HA, Kinsella A. Geographic Variations in the Prevalence of Schizophrenia-Reply. Arch Gen Psychiatry. 1992;49(11):907-908. doi:10.1001/archpsyc.1992.01820110071014.

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