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Single Photon Emission Computed Tomography in Obsessive-Compulsive Disorder-Reply

Lewis R. Baxter Jr, MD; John C. Mazziotta, MD, PhD
Arch Gen Psychiatry. 1993;50(6):499-500. doi:10.1001/archpsyc.1993.01820180101016.
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Harris et al rightly address the neuroanatomical localization of brain regions referred to as "orbital-frontal" vs "medial-frontal" in functional neuroimaging studies of OCD. They try to be more precise by referring to Brodmann areas.

Unfortunately, Brodmann identified brain regions based on microscopic cytoarchitecture, rather than sulci and gyri. Surface anatomy does not have a consistent and precise correspondence to Brodmann areas from one brain region to another, or across human brains. Presently neuroimaging studies depend on gross anatomy.

In our PET studies of OCD, we have used surface anatomy to approximate the location of the orbital gyri. According to our source,' the orbital gyri, as we identify them, would correspond—roughly—to most of Brodmann area 11 (except the gyri recti), but could well include portions of area 47, and possibly inferior regions of area 10. In Figure 4 of their article, Rubin et al2 seem to indicate regions of increased


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