Article |

Euphorogenic Properties of the Serotonergic Partial Agonist m-Chlorophenylpiperazine in Cocaine Addicts

Laure Buydens-Branchey, MD; Marc Branchey, MD; Craig McKernin, PA; Paul Fergeson, MA
Arch Gen Psychiatry. 1993;50(12):1001-1002. doi:10.1001/archpsyc.1993.01820240085012.
Text Size: A A A
Published online

The role played by alterations in serotonergic function in cocaine addiction is mostly unexplored in humans. To explore this, we studied the behavioral, physiological, and endocrine responses of cocaine addicts to challenges with either a placebo or with the serotonin partial agonist m-chlorophenylpiperazine hydrochloride (m-CPP). Nineteen patients who were in good physical health, whose drug of choice was cocaine and had used it almost exclusively during the year preceding our study, and who met DSM-III-R diagnostic criteria for cocaine dependence or abuse were included in the study. Their mean (±SD) age was 35.1 ±7.2 years. They were tested after admission to our inpatient drug rehabilitation unit. The mean (±SD) number of days elapsed since drug discontinuation was 15.1 ±6.6. Patients received m-CPP (0.5 mg/kg) or placebo in identical capsules, in random sequence, at 9:30 AM, with a 2-day interval between test days and according to a double-blind


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.