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Psychoneuroimmunology and Human Immunodeficiency Virus Type 1 Infection Revisited-Reply

Samuel Perry, MD; Judith Rabkin, PhD
Arch Gen Psychiatry. 1994;51(3):247-248. doi:10.1001/archpsyc.1994.03950030083008.
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In reply  There is currently a debate regarding how liberally or conservatively researchers in psychoimmunology should interpret occasional and inconsistent correlations between psychosocial and immune variables.1 We thank Goodkin et al because their impassioned letter and our more cautious tone2,3 capture the nature of this debate.In their first criticism, our Miami colleagues are concerned that we did not use the right hypotheses or measures. Another reading of our articles should help assure them that we tested hypotheses based on the cited psychoimmune literature and that we used a broad set of standardized psychiatric and psychosocial measures used in psychoimmune research. Many of our instruments did not assess psychopathology, but rather assessed the same constructs used by the Miami group (eg, social support, hardiness, and life stressors).In response to their second criticism, we believe it was not necessary to control for all the many factors that may affect immune


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