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Familial Obsessive-Compulsive Disorder Presenting as Pathological Jealousy Successfully Treated With Fluoxetine

Simon Wright, MB, ChB, MRCPsych
Arch Gen Psychiatry. 1994;51(5):430-431. doi:10.1001/archpsyc.1994.03950050090015.
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P jealousy in some patients is hypothesized as a variant of obsessive-compulsive disorder (OCD).1 A patient is presented herein who belonged to a pedigree of multiply affected members, suffered from pathological jealousy and features of OCD, and responded successfully to treatment with high-dose fluoxetine hydrochloride.

A 36-year-old twice-married woman presented in 1990 suffering from marital problems. Previous assessments noted the presence of pathological jealousy with no additional diagnosis given. She reported anxiety when she was separated from her husband, obsessional fears of his infidelity, and an obsessional thought that he was being unfaithful. These symptoms, evident 15 years ago during her first marriage, were more severe since her second marriage in 1986.

A family history revealed three relatives reported as having excessive jealousy to a degree that affected social relationships. Her maternal grandmother would cut out all the pictures of women from any literature to prevent her husband from


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