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Retrocallosal White Matter Abnormalities in Patients With Obsessive-compulsive Disorder

Hans C. Breiter, MD; Pauline A. Filipek, MD; David N. Kennedy, PhD; Lee Baer, PhD; Dawn A. Pitcher; Michael J. Olivares; Perry F. Renshaw, MD, PhD; Verne S. Caviness Jr, MD, DPhil; Michael A. Jenike, MD
Arch Gen Psychiatry. 1994;51(8):663-664. doi:10.1001/archpsyc.1994.03950080075010.
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Many studies have implicated the orbital gyrus and caudate nucleus as factors in obsessive-compulsive disorder (OCD).1 However, several recent neuropsychological and positron emission tomographic imaging studies have suggested that posterior parts of the brain may also be involved.2-6 Based on these findings, it is possible that OCD symptoms might result from a problem with higher-level perceptual Processing in the retrocallosal region, which could have an underlying structural substrate.

To study this hypothesis, using morphometric volume analysis of the retrocallosal region, we performed magnetic resonance imaging (MRI) scans of six female patients with OCD and eight female controls matched for age (mean±SD age of patients: 30.8±5.7 years; range, 20 to 37years; mean age of controls: 27.3±5.3 years; range, 17 to 33 years), handedness, and education (five of six OCD patients had a college or graduate education; all controls had a college or graduate education). The patients had been moderately


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