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Mania Induced by Citalopram

Christian Bryois, MD; François Ferrero, MD
Arch Gen Psychiatry. 1994;51(8):664-665. doi:10.1001/archpsyc.1994.03950080076011.
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Citalopram is an antidepressant that acts by inhibiting the reuptake of serotonin and that has been recently introduced into Switzerland. An investigation has shown that about 10% of the depressed patients who were treated using tricyclics or monoamine oxidase inhibitors have antidepressant-associated hypomanic or manic episodes.1 Some authors2-5 propose that such patients suffer from misdiagnosed bipolar disorder. Three serotonin reuptake inhibitors (fluoxetine,6,7 fluvoxamine,8,9 and paroxetine10) have been implicated in the appearance of manic and hypomanic episodes when used in therapeutic doses. This letter describes a manic episode induced by citalopram.

A major depressive episode of moderate intensity (296.32 of the DSM-III-R) associated with alcohol abuse (305.00 of the DSM-III-R) developed in a 52-year-old man with no personal or family history of depression or bipolar disorder. He required psychiatric hospitalization because of a high suicide risk. He was given febarbamate (a sedative commonly used in Europe)

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