We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Serotonin2A Receptors in Schizophrenia: Relation to Suicide

Herbert Y. Meltzer, MD
Arch Gen Psychiatry. 1994;51(12):1003. doi:10.1001/archpsyc.1994.03950120075015.
Text Size: A A A
Published online


Larulle et al1 reported no difference in B max (maximum number of ligand-binding sites) for serotonin2A (5-HT2A) receptors in the frontal cortex of six schizophrenic patients and six schizoaffective patients compared with 13 normal controls, using tritiated ketanserin as a ligand. There was a trend for Bmax to be decreased in both patient groups compared with nine nonpsychotic suicide victims. The psychotic patients included seven suicides and five nonsuicides. According to the abstract in their article, the Bmax of the five chronic psychotics who died of natural causes was less than that of the controls, the psychotics dying of suicide, and the nonpsychotic suicide victims. However, no statistical analysis to support this potentially important difference between schizophrenic or schizoaffective patients who suicided and those who did not was provided.

The authors should have cited our data,2 published in 1991, of a significant decrease in B


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.