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Serotonin2A Receptors in Schizophrenia: Relation to Suicide-Reply

Marc Laruelle, MD; Manuel F. Casanova, MD; Daniel R. Weinberger, MD; Joel E. Kleinman, MD, PhD; Anissa Abi-Dargham, MD
Arch Gen Psychiatry. 1994;51(12):1003-1004. doi:10.1001/archpsyc.1994.03950120075016.
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In reply  The density of 5-HT2 receptors in the frontal cortex of patients with schizophrenia has been reported to be decreased in three studies1-3 and unchanged in four studies.4-7 Obviously, this discrepancy could be due to several factors, such as differences in ligands (iodine 125—labeled LSD vs tritiated ketanserin vs tritiated spiperone), differences in prior medication exposure, or differences in theclinical and demographic characteristics of the patients.In our study, the patients with schizophrenia who died of natural causes had frontal 5-HT2 receptor Bmax values (mean±SEM; n=7, 76±16 fmol/mg of protein) significantly lower than controls (n=13, 164±14 fmol/mg of protein), schizophrenic patients who committed suicide (n=5, 162±25 fmol/mg of protein), and nonschizophrenic suicide victims (n=9, 205±22 fmol/mg of protein). The overall difference among groups was significant (analysis of covariance, P=.006) and the post hoc comparison revealed that the group of patients with schizophrenia who died of


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