Article |

In Pursuit of the Molecular Neuropathology of Schizophrenia-Reply

Scharam Akbarian, MD, PhD; Edward G. Jones, MD, PhD
Arch Gen Psychiatry. 1995;52(4):277-278. doi:10.1001/archpsyc.1995.03950160027006.
Text Size: A A A
Published online

In reply  Each of the three commentaries on our article1 raises important issues for discussion.Lee and Tobin2 claim a discrepancy between our findings of reduced glutamic acid decarboxylase messenger RNA (GAD mRNA) levels in the prefrontal cortex of schizophrenics and the lack of similar changes in GAD enzyme activity reported by Hanada et al.3 This is not surprising, given the fact that GAD enzyme is unstable and its activity is influenced by confounding factors such as autolysis time4 and cause of death.3,5 Two other studies reported decreased GAD activity in schizophrenics,6,7 but one only found decreased GAD activity in schizophrenics who did not die a sudden death.5 The GAD mRNA is far more resistant to autolysis, and localization by in situ hybridization was successful in all patients and controls included in this study. In the same specimens, staining of GAD enzyme by means


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.