0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Risk of Alzheimer's Disease in First-Degree Relatives

Reinhard Heun, MD; Wolfgang Maier, MD
Arch Gen Psychiatry. 1995;52(4):317-318. doi:10.1001/archpsyc.1995.03950160067014.
Text Size: A A A
Published online

In an article published in the July 1994 issue of the Archives, Silverman et al1 reported on the risks of first-degree relatives of patients with Alzheimer's disease for primary progressive dementia (PPD). They used the family history method for the evaluation of relatives and survival analysis for statistical calculations. The most remarkable finding was a reduction of the hazard rates in the 85- to 89-year age interval in the patient sample and, consequently, the reduction of the familial contribution to the risk for PPD compared with relatives of controls in this age range.

The study had two important shortcomings: first, relatives had not been interviewed personally; second, different informants provided family history information (ie, one or two relatives in the patient group and in the first control group and the index proband in the second control group). When using family history information, it might be that an age-dependent variation

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();