Clozapine-Induced Increase in Plasma Levels of Soluble Interleukin-2 Receptors-Reply

In reply  Rosebush and Mazurek are correct in acknowledging the complexities involved in an investigation of akathisia; these complexities are such that all aspects of the disorder cannot be addressed in one study. Because acute akathisia usually occurs in patients who also have acute psychosis, the management of psychosis and the control of behavior assume priority over demands made by a fastidious researcher. I, therefore, accept certain deficiencies in our research, some of which we have already acknowledged in our article.¹The issue of the use of benzodiazepines is extremely relevant, and we did not disregard it. In our study protocol, the use of a benzodiazepine at bedtime on an "as required" basis (which was decided by the resident physician) was permitted. The majority (56%) received such medication in the first 3 days, and fewer (10%), subsequently. In five patients, the use of a benzodiazepine was consistent throughout the 2 weeks of