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Schizophrenia and Temporal Lobe Epilepsy-Reply

James M. Gold, PhD; Bruce P. Hermann, PhD; Daniel R. Weinberger, MD
Arch Gen Psychiatry. 1996;53(11):1063-1065. doi:10.1001/archpsyc.1996.01830110101019.
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RESPONSE TO DR ANAND  Dr Anand suggests the possibility that the group differences we reported might be the result of numerous confounding variables, such as medication effects, the effect of institutionalization, deterioration in psychosocial skills, or the effect of psychotic symptoms. Although these variables are important, we do not think that our results are likely due to such confounding variables for several reasons. We do not see any basis for concluding that psychosocial handicaps, shared to varying degrees by all the patients in the study, can provide a principled account for differences in group performance profile. It would seem most likely to us that the cohort with severe chronic SCZ has experienced even more severe handicaps than the patients with TLE but still managed to perform better than the patients with epilepsy on several measures. Similarly, the English-language literature about medication effects in patients with SCZ does not support the


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