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The Relationship Between Plasma Haloperidol Concentrations and Clinical Results

Diego J. Palao, MD; Alberte Araùxo, MD; Josep M. Haro, MD; Mercé Brunet, MD; Miguel Bernardo, PhD
Arch Gen Psychiatry. 1996;53(12):1167-1168. doi:10.1001/archpsyc.1996.01830120107019.
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The article by Volavka et al1 in the October 1995 issue of the Archives supports the existence of an upper limit of haloperidol plasma concentrations of approximately 12 ng/mL for the treatment of patients with acutely exacerbated schizophrenia.

Volavka et al1 do not report a clear lower limit for the antipsychotic activity of plasma concentrations of haloperidol. The authors suggest that a "continuous increase of antipsychotic activity from levels close to 0 to approximately 12 ng/mL" exists.1 However, the definition of a minimum haloperidol plasma concentration for a meaningfulantipsychotic effect may have clinical relevance. The reanalysis of their data using the lower limit found in our study2 showed that while only 54.8% of the patients with plasma concentrations less than 5.5 ng/mL were considered improved, the value for patients with concentra


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