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Circadian Rest-Activity Disturbances in Seasonal Affective Disorder

Martin H. Teicher, MD, PhD; Carol A. Glod, RN, PhD; Eleanor Magnus; David Harper; Gregory Benson; Kathryn Krueger, MD; Cynthia E. McGreenery
Arch Gen Psychiatry. 1997;54(2):124-130. doi:10.1001/archpsyc.1997.01830140034007.
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Background:  Previous studies hypothesized that seasonal affective disorder (SAD) was caused by a circadian rhythm abnormality. The purpose of this study was to ascertain whether rest-activity rhythms were phase delayed, diminished in amplitude, or more poorly entrained to the 24-hour day.

Method:  Twenty healthy adult controls and 25 outpatients meeting Rosenthal—National Institute of Mental Health criteria for SAD and DSM-III-R criteria for major or bipolar depression with seasonal pattern had their levels of activity recorded for 72 hours (weekdays) using wrist-worn actigraphs.

Results:  Subjects with SAD had activity levels that were 11% lower than controls (P=.03), and their levels of activity were most attenuated during the first 2 hours after arising (P=.004). The relative amplitude of the circadian rhythm did not differ between groups. Patients with SAD were phase delayed by 50 minutes for the entire period (P=.02). Analysis of each individual day indicated that patients were delayed by up to 70 minutes (P=.007). Interdaily stability, an index of coupling between the rhythm and its zeitgeber was reduced in SAD (P=.01). Compared with controls, patients with SAD had best-fit circadian periods that were 92% more deviated from 24 hours (P=.007) and daily acrophase (time of the peak of the fit circadian rhythm) times that were 110% more variable between days (P<.001).

Conclusions:  Patients with SAD have circadian restactivity rhythms that are significantly phase delayed and more poorly entrained to the 24-hour day.

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