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Phosphorus 31 Magnetic Resonance Spectroscopy in Patients With Huntington Disease

Peter C. Williamson, MD; Ashok Malla, MD; Jeff A. Stanley, PhD; Len Cortese, MD; A. Jon Stoessl, MD; Dick Drost, PhD
Arch Gen Psychiatry. 1997;54(2):186-187. doi:10.1001/archpsyc.1997.01830140098016.
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Phosphorus 31 magnetic resonance spectroscopy (MRS) provides in vivo information about membrane phospholipid and high-energy phosphate metabolism in the brain.1 We recently described31P MRS findings in never-treated patients with schizophrenia compared with matched control subjects.2 These patients were found to have lower concentrations of phosphomonoesters and increased concentrations of phosphodiesters and calculated intracellular magnesium in the prefrontal region compared with matched control subjects. We report a case of Huntington disease (HD) that was inadvertently included in our31P MRS study in the nevertreated group with schizophrenia.2

Report of a Case. A 19-year-old man had a 3- to 4-year history of deterioration in general functioning, increased social withdrawal, positive symptoms, and a recent history of bizarre purposeless behavior and poor judgement. The patient reported alien thoughts and ideas of reference. He demonstrated poverty of thought, flat affect, thought blocking, and poor abstraction with no perceptual


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