Article |

The Clinical Course of Unipolar Major Depressive Disorders

Lewis L. Judd, MD
Arch Gen Psychiatry. 1997;54(11):989-991. doi:10.1001/archpsyc.1997.01830230015002.
Text Size: A A A
Published online

A FUNDAMENTAL paradigmatic shift is occurring in the understanding of unipolar major depressive disorders (MDD) among the general public, by many public health experts, and by the practicing psychiatric community. Most people in our society no longer view depression as a mysterious sickness of spirit or emotional weakness, but rather as a disease of the brain and an important health problem.1 International public health experts acknowledge the high prevalence of unipolar MDD2 combined with the pervasive human misery and impairment associated with it, and have identified this disease in 1990 as the fourth-ranked cause of disability and premature death worldwide.3 In parallel, the treatment of unipolar MDD has evolved from incarceration, exorcism, and prayer to classic psychoanalysis, and now in the modern era to treatment with empirically proven, effective antidepressant medications and depression-specific brief psychotherapies. Meta-analyses of 6 standardized treatment studies by Thase et al4 have


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.