Acknowledgment: Gratitude is expressed to our colleagues for contributing to this research. Robert J. DeRubeis, PhD, and Steven D. Hollon, PhD, were the principal investigators and oversaw the implementation of cognitive therapy at the respective sites. Jay D. Amsterdam, MD, and Richard C. Shelton, MD, were the co-principal investigators and supervised the implementation of medication treatment. Edward Schweizer, MD, provided important consultation about study design and implementation, especially early in the trial. Paula R. Young, PhD, and Margaret L. Lovett, MEd, served as the study coordinators. John P. O’Reardon, MD, Ronald M. Salomon, MD, and the late Martin Szuba, MD, served as study pharmacotherapists (along with Drs Amsterdam and Shelton). Cory P. Newman, PhD, Karl N. Jannasch, PhD, Frances Shusman, PhD, and Sandra Seidel, MSN, served as the cognitive therapists (along with Drs DeRubeis and Hollon). Jan Fawcett, MD, provided consultation with regard to the implementation of clinical management pharmacotherapy. Aaron T. Beck, MD, Judith Beck, PhD, Christine Johnson, PhD, and Leslie Sokol, PhD, provided consultation with respect to the implementation of cognitive therapy. Madeline M. Gladis, PhD, and Kirsten L. Haman, PhD, oversaw the training of the clinical interviewers, and David Appelbaum, PsyD, Laurel L. Brown, PhD, Richard C. Carson, PhD, Barrie Franklin, PhD, Nana A. Landenberger, PhD, Jessica Londa-Jacobs, PhD, Julie L. Pickholtz, PhD, Pamela Fawcett-Pressman, MEd, Sabine Schmid, MA, Ellen D. Stoddard, PhD, Michael Suminski, PhD, and Dorothy Tucker, PhD, served as project interviewers. Robert Gallop, PhD, and Andrew J. Tomarken, PhD, provided statistical consultation. Joyce L. Bell, BA, Brent B. Freeman, BA, Cara C. Grugan, BA, Nathaniel R. Herr, BA, Mary B. Hooper, MS, Miriam Hundert, BSN, Veni Linos, MSc, and Tynya Patton, MA, provided research support. Kelly Bemis Vitousek, PhD, provided helpful comments on an earlier draft of the manuscript.