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Reevaluation of Heterophile Hemolytic Response in Psychiatric Patients

Samuel Gershon, MBBS, DPM; Baron Shopsin, MD; John R. Bergen, PhD; Lorraine Pinckney, MT
[+] Author Affiliations

Submitted for publication April 19, 1968.

Reprint requests to New York University Medical Center, 550 First Ave, New York 10016 (Dr. Gershon).


Arch Gen Psychiatry. 1968;19(5):611-615. doi:10.1001/archpsyc.1968.01740110099011
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IN 1947, Sjovall1 reported occurrence of hemoglobin in the urine of mice following injection of serum of schizophrenics and loss of this activity of serum following heating at 56 C for one half hour. Turner and Chipps pursued this lead and in 1966 reported2 that there is an antirabbit heterophil hemolysin of widespread occurrence in human serum. Their study indicated that this hemolysin was present at higher levels in the serum of schizophrenics than those of other persons.

The interest aroused by this notion of heterophil hemolysins as another3 potential "biochemical lesion" in schizophrenia prompted further investigation. Operating essentially within the same framework as Turner and Chipps, the data we collected fails to indicate a difference between schizophrenic and nonschizophrenic populations with respect to serum hemolysis of rabbit erythrocytes.

Methods  Blood was drawn in the morning from fasting subjects. One part of the

REFERENCES

Sjovall, T.:  Preliminary Studies on a Possible Serum Toxicity in Schizophrenia , Acta Psychiat Neurol ( (suppl) ) 47:105-117, 1947;.
Turner, W.J., and Chipps, H.I.:  A Heterophil Hemolysin in Human Blood: I. Distribution in Schizophrenics and NonSchizophrenics , Arch Gen Psychiat 15:373-377 ( (Oct) ) 1966;.
Friedhoff, A.J., and Van Winkle, E.:  Isolation and Characterization of a Compound From the Urine of Schizophrenics , Nature 194:867-868 ( (June) ) 1962;.
Kety, S.S.:  Biochemical Theories of Schizo Phrenia: I and II , Science 129:1528-1532 ( (June) ) 1959;
1590-1596 (June) 1959.
Gershon, S., and Lonigro, A.:  A Study of Lymphocytes Stained With Masson's Trichrome Stain in Masson's Trichrome Stain in Psychiatric Patients , J Nerv Ment Dis 138:569-573 ( (Dec) ) 1964;.
Shopsin, B., and Gershon, S.: The Effects of Sera From Psychiatric Patients on Guinea-Pig Brain Tissue Respiration, to be published.
Kety, S.S.:  Biochemical Theories of Schizophrenia , Int J Psychiat 1:409-446 ( (July) ) 1965;.
Perry, T., et al:  Urinary Amines of Intestinal Bacterial Origin , Clin chim Acta 14:116-123 ( (July) ) 1966;.
Friedhoff, A.J.:  Biochemical Effects of Experimental Diets , J Psychiat Res 5:265-271 ( (Sept) ) 1967;.
Horwitt, M.K.:  Fact and Artifact in the Biology of Schizophrenia , Science 124:429-430 ( (Sept) ) 1956;.
Willoughby, W.F., and Mayer, M.M.:  Antibody-Complement Complexes , Science 150:907-908 ( (Nov) ) 1965;.
Race, R.R., and Sanger, R.: Blood Groups in Man , 4th ed, Oxford, England: Blackwell Scientific Publications, 1962;, pp 49-50.
Irvine, D.G., and Miyashita, H.:  Blood Types in Relation to Depressions and Schizophrenia: A Preliminary Report , Canad Med Assoc J 92:551-554 ( (March) ) 1965;.
Cushing, J.E., and Campbell, D.H.: Principles of Immunology , New York: McGraw-Hill Book Co., Inc., 1958; pp 148-149.
Friedberger, quoted by Davidson, I.:  Heterophilic Antibodies in Serum Disease , J Infect Dis 53:219-229 ( (Sept-Oct) ) 1933;.

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Sjovall, T.:  Preliminary Studies on a Possible Serum Toxicity in Schizophrenia , Acta Psychiat Neurol ( (suppl) ) 47:105-117, 1947;.
Turner, W.J., and Chipps, H.I.:  A Heterophil Hemolysin in Human Blood: I. Distribution in Schizophrenics and NonSchizophrenics , Arch Gen Psychiat 15:373-377 ( (Oct) ) 1966;.
Friedhoff, A.J., and Van Winkle, E.:  Isolation and Characterization of a Compound From the Urine of Schizophrenics , Nature 194:867-868 ( (June) ) 1962;.
Kety, S.S.:  Biochemical Theories of Schizo Phrenia: I and II , Science 129:1528-1532 ( (June) ) 1959;
1590-1596 (June) 1959.
Gershon, S., and Lonigro, A.:  A Study of Lymphocytes Stained With Masson's Trichrome Stain in Masson's Trichrome Stain in Psychiatric Patients , J Nerv Ment Dis 138:569-573 ( (Dec) ) 1964;.
Shopsin, B., and Gershon, S.: The Effects of Sera From Psychiatric Patients on Guinea-Pig Brain Tissue Respiration, to be published.
Kety, S.S.:  Biochemical Theories of Schizophrenia , Int J Psychiat 1:409-446 ( (July) ) 1965;.
Perry, T., et al:  Urinary Amines of Intestinal Bacterial Origin , Clin chim Acta 14:116-123 ( (July) ) 1966;.
Friedhoff, A.J.:  Biochemical Effects of Experimental Diets , J Psychiat Res 5:265-271 ( (Sept) ) 1967;.
Horwitt, M.K.:  Fact and Artifact in the Biology of Schizophrenia , Science 124:429-430 ( (Sept) ) 1956;.
Willoughby, W.F., and Mayer, M.M.:  Antibody-Complement Complexes , Science 150:907-908 ( (Nov) ) 1965;.
Race, R.R., and Sanger, R.: Blood Groups in Man , 4th ed, Oxford, England: Blackwell Scientific Publications, 1962;, pp 49-50.
Irvine, D.G., and Miyashita, H.:  Blood Types in Relation to Depressions and Schizophrenia: A Preliminary Report , Canad Med Assoc J 92:551-554 ( (March) ) 1965;.
Cushing, J.E., and Campbell, D.H.: Principles of Immunology , New York: McGraw-Hill Book Co., Inc., 1958; pp 148-149.
Friedberger, quoted by Davidson, I.:  Heterophilic Antibodies in Serum Disease , J Infect Dis 53:219-229 ( (Sept-Oct) ) 1933;.

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