Submitted for publication Oct 1, 1969.
Reprint requests to the Department of Pathology, School of Medicine, University of Hawaii, Honolulu 96816 (Dr. Hokama).
CHRONIC brain syndrome is characterized by diffuse, irreversible damage to brain tissue function of unknown etiology.1 The patient experiences progressive impairment of orientation, memory, intellect, judgment, and affect. Electroencephalogram findings often reflect diffuse brain damage. At present, the prognosis is poor. Psychotic and neurotic personality disturbances related to preexisting personality patterns frequently arise.
Two major mechanisms have been proposed to account for autoimmune disease: (1) breakdown in sequestration of antigen (Ag) and (2) loss of immune tolerance. Several investigators have suggested that certain Ag like thyroglobulin, lens protein, and central nervous system (CNS) Ag are normally sequestered and do not constitute accessible Ag.2 One may predict that an injury or pathologic process which allows these normally sequestered CNS Ag to escape into the general circulation would create accessible Ag leading to immune response. This may be of either the circulating antibody (ab) type or cellular immunity type. As
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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