0
September 1977, Vol 34, No. 9 >
Article | September 1977

Psychologic and Neuroendocrine Response to Methylphenidate

Walter Armin Brown, MD
[+] Author Affiliations

Accepted for publication March 31, 1977.

Reprint requests to Neuroendocrine Research Laboratory, Veterans Administration Hospital, Davis Park, Providence, RI 02908 (Dr Brown).


Arch Gen Psychiatry. 1977;34(9):1103-1108. doi:10.1001/archpsyc.1977.01770210117011
Text Size: A A A
Published online
Article
References
Comments

• The value of neuroendocrine techniques for providing information regarding the pathophysiology of psychotic disorders is largely dependent on clarification of the relationships among psychologic state, neural activity, and neuroendocrine regulation. This study presents a strategy for examining the interface between neurochemical activity, psychologic state, and neuroendocrine regulation. Psychologic state and serum growth hormone (GH) and cortisol were monitored following administration of methylphenidate hydrochloride, a drug that appears to preferentially affect central dopamine regulation. While individuals varied in both their endocrine and psychologic responses to methylphenidate, the general effects were GH elevation, euphoria, and activation with elation, the most pronounced psychologic effect. Subjects who showed GH elevation became elated while those who did not show a GH response did not become elated. Elation and GH release following administration of methylphenidate may be mediated by the same neurochemical events.

REFERENCES

1 +
Sachar EJ, Frantz AG, Altman N, et al:  Growth hormone and prolactin in unipolar and bipolar depressed patients . Am J Psychiatry 130:1361-1367, 1973;.
2 +
Sachar EJ, Hellman L, Roffwarg HP, et al:  Disrupted 24-hour patterns of cortisol secretion in psychotic depression . Arch Gen Psychiatry 28:19-24, 1973;.
3 +
Garver DL, Pandey GN, Dekirmenjian H:  Growth hormone and catecholamines in affective disease . Am J Psychiatry 132:1149-1154, 1975;.
4 +
Scheel-Krüger J:  Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of the catecholamines in the brain . Eur J Pharmacol 14:47-59, 1971;.
5 +
Ferris R, Tang F, Maxwell R:  A comparison of the capacities of isomers of amphetamine, deoxypipradrol and methylphenidate to inhibit the uptake of tritiated catecholamines into rat cerebral cortex slices, synaptosomal preparations of rat cerebral cortex, hypothalamus and striatum and into adrenergic nerves of rabbit aorta . J Pharmacol Exp Therap 181:407-416, 1972;.
6 +
Costall B, Naylor RJ:  The involvement of dopaminergic systems with the stereotyped behavior patterns induced by methylphenidate . J Pharm Pharmacol 26:20-33, 1974;.
7 +
Franklin KBJ, Herberg LJ:  Self-stimulation and catecholamines: Drug-induced mobilization of the "reserve" pool re-establishes responding in catecholamine-depleted rats . Brain Res 67:429-437, 1974;.
8 +
Martin WR, Sloan JW, Sapira JD, et al:  Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phen metrazine and methylphenidate in man . Clin Pharmacol Therap 12:245-258, 1971;.
9 +
Janowsky DS, Davis JM:  Methylphenidate, dextroamphetamine and levamfetamine: Effects on schizophrenic symptoms . Arch Gen Psychiatry 33:304-308, 1976;.
10 +
Martin JB:  Neural regulation of growth hormone secretion . N Engl J Med 288:1384-1393, 1973;.
11 +
DeWied D, DeJong W:  Drug effects and hypothalamic-anterior pituitary function . Annu Rev Pharmacol 14:389-412, 1974;.
12 +
Brown WA, Williams BW:  Methylphenidate increases serum growth hormone concentrations . J Clin Endocr Metab 43:937-939, 1976;.
13 +
Nowlis V: Research with the Mood Adjective Check List, in Affect, Cognition, and Personality , Tomkins SS, Izard CE (eds). New York, Springer-Verlag, 1965;.
14 +
Boden G, Soeldner JS:  A sensitive double antibody radioimmunoassay for human growth hormone (HGH): Levels of serum HGH following rapid tolbutamide infusion . Diabetolgia 8:413-421, 1967;.
15 +
Murphy BEP:  Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay . J Clin Endocrinol 27:973-990, 1967;.
16 +
Krieger DT:  Rhythm of ACTH and corticosteroid secretion in health and disease and their experimental modification . J Steroid Biochem 6:785-791, 1975;.
17 +
Besser GM, Butler PWP, Landon J, et al:  Influence of amphetamines on plasma corticosteroid and growth hormone levels in man . BrJMed 4:523-530, 1969;.
18 +
Brown WA, Heninger G:  Cortisol, growth hormone, free fatty acids and experimentally evoked affective arousal . Am J Psychiatry 132:1172-1176, 1975;.
19 +
Brown WA, Heninger G:  Stress-induced growth hormone release: Psychologic and physiologic correlates . Psychosom Med 38:145-147, 1976;.
20 +
Greene WA, Conron G, Schalch DS, et al:  Psychologic correlates of growth hormone and adrenal scretory responses of patients undergoing cardiac catheterization . Psychosom Med 32:599-614, 1970;.
21 +
Brown WA, VanWoert MH, Ambani JM:  Effect of apomorphine on growth hormone release in humans . J Clin Endocr Metab 37:463-467, 1973;.
22 +
Goodwin FK:  Psychiatric side-effects of levodopa in man . JAMA 218:1915-1920, 1971;.
23 +
Murphy D, Goodwin FK, Brodie KH, et al:  L-dopa, dopamine and hypomania . Am J Psychiatry 130:79-82, 1973;.

First Page Preview

First page PDF preview

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Sachar EJ, Frantz AG, Altman N, et al:  Growth hormone and prolactin in unipolar and bipolar depressed patients . Am J Psychiatry 130:1361-1367, 1973;.
2 +
Sachar EJ, Hellman L, Roffwarg HP, et al:  Disrupted 24-hour patterns of cortisol secretion in psychotic depression . Arch Gen Psychiatry 28:19-24, 1973;.
3 +
Garver DL, Pandey GN, Dekirmenjian H:  Growth hormone and catecholamines in affective disease . Am J Psychiatry 132:1149-1154, 1975;.
4 +
Scheel-Krüger J:  Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of the catecholamines in the brain . Eur J Pharmacol 14:47-59, 1971;.
5 +
Ferris R, Tang F, Maxwell R:  A comparison of the capacities of isomers of amphetamine, deoxypipradrol and methylphenidate to inhibit the uptake of tritiated catecholamines into rat cerebral cortex slices, synaptosomal preparations of rat cerebral cortex, hypothalamus and striatum and into adrenergic nerves of rabbit aorta . J Pharmacol Exp Therap 181:407-416, 1972;.
6 +
Costall B, Naylor RJ:  The involvement of dopaminergic systems with the stereotyped behavior patterns induced by methylphenidate . J Pharm Pharmacol 26:20-33, 1974;.
7 +
Franklin KBJ, Herberg LJ:  Self-stimulation and catecholamines: Drug-induced mobilization of the "reserve" pool re-establishes responding in catecholamine-depleted rats . Brain Res 67:429-437, 1974;.
8 +
Martin WR, Sloan JW, Sapira JD, et al:  Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phen metrazine and methylphenidate in man . Clin Pharmacol Therap 12:245-258, 1971;.
9 +
Janowsky DS, Davis JM:  Methylphenidate, dextroamphetamine and levamfetamine: Effects on schizophrenic symptoms . Arch Gen Psychiatry 33:304-308, 1976;.
10 +
Martin JB:  Neural regulation of growth hormone secretion . N Engl J Med 288:1384-1393, 1973;.
11 +
DeWied D, DeJong W:  Drug effects and hypothalamic-anterior pituitary function . Annu Rev Pharmacol 14:389-412, 1974;.
12 +
Brown WA, Williams BW:  Methylphenidate increases serum growth hormone concentrations . J Clin Endocr Metab 43:937-939, 1976;.
13 +
Nowlis V: Research with the Mood Adjective Check List, in Affect, Cognition, and Personality , Tomkins SS, Izard CE (eds). New York, Springer-Verlag, 1965;.
14 +
Boden G, Soeldner JS:  A sensitive double antibody radioimmunoassay for human growth hormone (HGH): Levels of serum HGH following rapid tolbutamide infusion . Diabetolgia 8:413-421, 1967;.
15 +
Murphy BEP:  Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay . J Clin Endocrinol 27:973-990, 1967;.
16 +
Krieger DT:  Rhythm of ACTH and corticosteroid secretion in health and disease and their experimental modification . J Steroid Biochem 6:785-791, 1975;.
17 +
Besser GM, Butler PWP, Landon J, et al:  Influence of amphetamines on plasma corticosteroid and growth hormone levels in man . BrJMed 4:523-530, 1969;.
18 +
Brown WA, Heninger G:  Cortisol, growth hormone, free fatty acids and experimentally evoked affective arousal . Am J Psychiatry 132:1172-1176, 1975;.
19 +
Brown WA, Heninger G:  Stress-induced growth hormone release: Psychologic and physiologic correlates . Psychosom Med 38:145-147, 1976;.
20 +
Greene WA, Conron G, Schalch DS, et al:  Psychologic correlates of growth hormone and adrenal scretory responses of patients undergoing cardiac catheterization . Psychosom Med 32:599-614, 1970;.
21 +
Brown WA, VanWoert MH, Ambani JM:  Effect of apomorphine on growth hormone release in humans . J Clin Endocr Metab 37:463-467, 1973;.
22 +
Goodwin FK:  Psychiatric side-effects of levodopa in man . JAMA 218:1915-1920, 1971;.
23 +
Murphy D, Goodwin FK, Brodie KH, et al:  L-dopa, dopamine and hypomania . Am J Psychiatry 130:79-82, 1973;.

Correspondence

Submit a Letter
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2012 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems