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July 1982, Vol 39, No. 7 >
Article | July 1982

Computed Tomography in Schizophrenia: Title and subTitle BreakDisparities in the Prevalence of Abnormalities

Daniel J. Luchins, MD
[+] Author Affiliations

Accepted for publication May 3, 1982.

Reprint requests to Department of Psychiatry, Box 411, University of Chicago, 950 E 59th St, Chicago, IL 60637 (Dr Luchins).


Arch Gen Psychiatry. 1982;39(7):859-860. doi:10.1001/archpsyc.1982.04290070079015
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Comments

In 1976, Johnstone et al1 reported the first computed tomography (CT) study in schizophrenia. They observed enlarged lateral ventricles in more than 50% of their sample of middle-aged patients undergoing longterm hospitalization. Three years later, Weinberger et al2 studied a larger and younger population of research patients at the National Institute of Mental Health (NIMH), and they noted enlarged ventricles (2 SDs greater than normal) in a similar proportion. This group also reported enlarged cortical sulci3 and an increased frequency of reversed cerebral asymmetry.4 Subsequent studies have reported striking differences in the prevalence of ventricular enlargement in schizophrenia. For example, Golden et al5 noted enlarged ventricles in 60% of their sample, while Andreasen et al* noted it in only 6%. In this issue of the Archives, along with two reports of enlarged ventricles in schizophrenics by Nasrallah et al and Weinberger et al (see pp

REFERENCES

1 +
Johnstone EC, Crow TJ, Frith CD, et al:  Cerebral ventricular size and cognitive impairment in chronic schizophrenia . Lancet 1976;;2:924-926.
2 +
Weinberger DR, Torrey EF, Neophytides AN, et al:  Lateral cerebral ventricular enlargement in chronic schizophrenia . Arch Gen Psychiatry 1979;;36:735-739.
3 +
Weinberger DR, Torrey EF, Neophytides AN, et al:  Structural abnormalities in the cerebral cortex of chronic schizophrenic patients . Arch Gen Psychiatry 1979;;36:935-939.
4 +
Luchins DJ, Weinberger DR, Wyatt RJ:  Schizophrenia: Evidence of a subgroup with reversed cerebral asymmetry . Arch Gen Psychiatry 1979;;36:1309-1311.
5 +
Golden CJ, Moses JA, Zelazowski MA, et al:  Cerebral ventricular size and neuropsychological impairment in young chronic schizophrenics: Measurement by standardized Luria-Nebraska neuropsychological battery . Arch Gen Psychiatry 1980;;37:619-623.
6 +
Andreasen NC, Smith MR, Jacoby CG, et al:  Ventricular enlargement in schizophrenia: Definition and prevalence . Am J Psychiatry 1982;;139:292-296.
7 +
Weinberger DR, Bigelow LB, Kleinman JE, et al:  Cerebral ventricular enlargement in chronic schizophrenia: An association with poor response to treatment . Arch Gen Psychiatry 1980;;37:11-13.
8 +
Weinberger DR, Cannon-Spoor E, Potkin SG, et al:  Poor premorbid adjustment and CT scan abnormalities in chronic schizophrenia . Am J Psychiatry 1980;;137:1410-1413.
9 +
Andreasen NC, Olsen SA, Dennert JW, et al:  Ventricular enlargement in schizophrenia: Relationship to positive and negative symptoms . Am J Psychiatry 1982;;139:297-3112.
10 +
Haber G, Gross G, Schutter R:  A long-term follow-up study of schizophrenia: Psychiatric course of illness and prognosis . Acta Psychiatr Sea nd 1975;;52:49-57.
11 +
Naeser MA, Levine HL, Benson DF, et al:  Frontal leukotomy size and hemispheric asymmetries on computerized tomographic scans of schizojihrenics with variable recovery . Arch Nevrol 1981;;38:30-37.
12 +
Tsai I., Jacoby CG, Stewart MA, et al:  Unfavorable left-right asymmetries of the brain and autism: A question of methodology . Br J Psych iati-y 1982;;140:312-319.
13 +
LeMay M:  Asymmetries of the skull and handedness: Phrenology revisited . J Neurol Sci 1977;;32:243-253.
14 +
Chui HC, Damasio AR:  Human cerebral asymmetries evaluated by computed tomography . J Neural Neurosnrg Psychiatry 1980;;43:873-878.
15 +
Andreasen NC, Dennert JW, Olsen SA, et al:  Hemispheric asymmetries and schizophrenia . Am J Psychiatry 1982;;139:427-430.
16 +
Hier DB, LeMay M, Rosenberger PB:  Autism and unfavorable leftright asymmetries of the brain . J Autism Dev Disord 1979;;9:153-159.

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1 +
Johnstone EC, Crow TJ, Frith CD, et al:  Cerebral ventricular size and cognitive impairment in chronic schizophrenia . Lancet 1976;;2:924-926.
2 +
Weinberger DR, Torrey EF, Neophytides AN, et al:  Lateral cerebral ventricular enlargement in chronic schizophrenia . Arch Gen Psychiatry 1979;;36:735-739.
3 +
Weinberger DR, Torrey EF, Neophytides AN, et al:  Structural abnormalities in the cerebral cortex of chronic schizophrenic patients . Arch Gen Psychiatry 1979;;36:935-939.
4 +
Luchins DJ, Weinberger DR, Wyatt RJ:  Schizophrenia: Evidence of a subgroup with reversed cerebral asymmetry . Arch Gen Psychiatry 1979;;36:1309-1311.
5 +
Golden CJ, Moses JA, Zelazowski MA, et al:  Cerebral ventricular size and neuropsychological impairment in young chronic schizophrenics: Measurement by standardized Luria-Nebraska neuropsychological battery . Arch Gen Psychiatry 1980;;37:619-623.
6 +
Andreasen NC, Smith MR, Jacoby CG, et al:  Ventricular enlargement in schizophrenia: Definition and prevalence . Am J Psychiatry 1982;;139:292-296.
7 +
Weinberger DR, Bigelow LB, Kleinman JE, et al:  Cerebral ventricular enlargement in chronic schizophrenia: An association with poor response to treatment . Arch Gen Psychiatry 1980;;37:11-13.
8 +
Weinberger DR, Cannon-Spoor E, Potkin SG, et al:  Poor premorbid adjustment and CT scan abnormalities in chronic schizophrenia . Am J Psychiatry 1980;;137:1410-1413.
9 +
Andreasen NC, Olsen SA, Dennert JW, et al:  Ventricular enlargement in schizophrenia: Relationship to positive and negative symptoms . Am J Psychiatry 1982;;139:297-3112.
10 +
Haber G, Gross G, Schutter R:  A long-term follow-up study of schizophrenia: Psychiatric course of illness and prognosis . Acta Psychiatr Sea nd 1975;;52:49-57.
11 +
Naeser MA, Levine HL, Benson DF, et al:  Frontal leukotomy size and hemispheric asymmetries on computerized tomographic scans of schizojihrenics with variable recovery . Arch Nevrol 1981;;38:30-37.
12 +
Tsai I., Jacoby CG, Stewart MA, et al:  Unfavorable left-right asymmetries of the brain and autism: A question of methodology . Br J Psych iati-y 1982;;140:312-319.
13 +
LeMay M:  Asymmetries of the skull and handedness: Phrenology revisited . J Neurol Sci 1977;;32:243-253.
14 +
Chui HC, Damasio AR:  Human cerebral asymmetries evaluated by computed tomography . J Neural Neurosnrg Psychiatry 1980;;43:873-878.
15 +
Andreasen NC, Dennert JW, Olsen SA, et al:  Hemispheric asymmetries and schizophrenia . Am J Psychiatry 1982;;139:427-430.
16 +
Hier DB, LeMay M, Rosenberger PB:  Autism and unfavorable leftright asymmetries of the brain . J Autism Dev Disord 1979;;9:153-159.

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