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Urinary MHPG and Response to Amitriptyline

Ilan Modai, MD; Alan Apter, MD; Miriam Golomb, MD; Henricus Wijsenbeek, PhD, MD
Arch Gen Psychiatry. 1983;40(4):467-467. doi:10.1001/archpsyc.1983.01790040121018
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To the Editor.—  With reference to the article entitled "Receptor Sensitivity and the Mechanism of Action of Antidepressant Treatment" by Charney et al (Archives 1981;38:1160-1180), we disagree with the authors concerning our study on pretreatment urinary levels of 3-methoxy-4-hydroxyphenethyleneglycol (MHPG) as predictors of response to amitriptyline hydrochloride treatment. They stated that our results were nonconfirmative, but we actually did find significant differences between the responders to amitriptyline treatment (higher levels of MHPG) and the nonresponders (lower levels of MHPG).1 Our findings confirmed previous reports by Schildkraut2 and Beckman and Goodwin.3

REFERENCES

Modai I, Apter A, Golomb M, et al:  Response to amitriptyline and urinary MHPG in bipolar depressive patients . Neuropsychobiology 1979;;5:181-184.
Schildkraut J:  Norepinephrine metabolites as biochemical criteria for classifying depressive disorders and predicting responses to treatment: Preliminary findings . Am J Psychiatry 1973;;130:695-699.
Beckman H, Goodwin FK:  Antidepressant response to tricyclics and urinary MHPG in unipolar patients: Clinical response to imipramine or amitriptyline . Arch Gen Psychiatry 1975;;32:17-21.

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Modai I, Apter A, Golomb M, et al:  Response to amitriptyline and urinary MHPG in bipolar depressive patients . Neuropsychobiology 1979;;5:181-184.
Schildkraut J:  Norepinephrine metabolites as biochemical criteria for classifying depressive disorders and predicting responses to treatment: Preliminary findings . Am J Psychiatry 1973;;130:695-699.
Beckman H, Goodwin FK:  Antidepressant response to tricyclics and urinary MHPG in unipolar patients: Clinical response to imipramine or amitriptyline . Arch Gen Psychiatry 1975;;32:17-21.

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