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Cerebral Blood Flow in Schizophrenia

Isak Prohovnik, PhD; Harold A. Sackeim, PhD; Sidney Malitz, MD; Paolo Decina, MD
Arch Gen Psychiatry. 1983;40(7):811-811. doi:10.1001/archpsyc.1983.01790060109014
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To the Editor—  The article "Regional Cerebral Blood Flow in Schizophrenia" by Mathew et al (Archives 1982;39:1121-1124) deals with one of the major interfaces between the study of cerebral circulation and psychiatric conditions, and constitutes an important contribution to the field. Therefore, it is regretable that we must point out major problems and ambiguities in this work.A previous article by Mathew et al1 was criticized on the issue of inappropriate control comparisons.2 Their recent study used the same between-group design and unfortunately can be criticized on the same grounds. In such designs, the nature of the control group determines to a large extent the validity of any conclusion. The only information provided by Mathew et al about their controls was that they did not meet DSM-III criteria for schizophrenia, and were matched for age, sex, and handedness. Readers were not informed whether the controls were patients

REFERENCES

Mathew RJ, Meyer JS, Deshmukh KM, et al:  Cerebral blood flow in depression . Lancet 1980;; 1:1308.
Gustafson L, Risberg J, Silfverskiold P:  Cerebral blood flow in dementia and depression . Lancet 1981;;1:275.
Meyer JS, Ishihara N, Deshmukh VD, et al:  Improved method for noninvasive measurement of regional cerebral blood flow by 133xenon inhalation: I. Description of method and normal values obtained in healthy volunteers . Stroke 1978;;9:195-205.
Yamamoto M, Meyer JS, Sakai S, et al:  Aging and cerebral vasodilatory responses to hypercarbia: Responses in normal aging and in persons with risk factors for stroke . Arch Neurol 1980;;37:489-496.
Maximilian VA, Prohovnik I, Risberg J:  Cerebral hemodynamic response to mental activation in normo- and hypercapnia . Stroke 1980;; 11:342-347.
Ingvar DH, Franzen G:  Abnormalities in cerebral blood flow distribution in patients with chronic schizophrenia . Acta Psychiatr Scand 1974;;50:425-462.

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Mathew RJ, Meyer JS, Deshmukh KM, et al:  Cerebral blood flow in depression . Lancet 1980;; 1:1308.
Gustafson L, Risberg J, Silfverskiold P:  Cerebral blood flow in dementia and depression . Lancet 1981;;1:275.
Meyer JS, Ishihara N, Deshmukh VD, et al:  Improved method for noninvasive measurement of regional cerebral blood flow by 133xenon inhalation: I. Description of method and normal values obtained in healthy volunteers . Stroke 1978;;9:195-205.
Yamamoto M, Meyer JS, Sakai S, et al:  Aging and cerebral vasodilatory responses to hypercarbia: Responses in normal aging and in persons with risk factors for stroke . Arch Neurol 1980;;37:489-496.
Maximilian VA, Prohovnik I, Risberg J:  Cerebral hemodynamic response to mental activation in normo- and hypercapnia . Stroke 1980;; 11:342-347.
Ingvar DH, Franzen G:  Abnormalities in cerebral blood flow distribution in patients with chronic schizophrenia . Acta Psychiatr Scand 1974;;50:425-462.

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