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Brain Function in Psychiatric Disorders Reconsidered

John H. Gruzelier, PhD
Arch Gen Psychiatry. 1985;42(4):421-421. doi:10.1001/archpsyc.1985.01790270111013
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To the Editor.—  In a conceptually important study, Gur et al1 measured with the xenon Xe 133 inhalation technique the blood flow in the grey matter of the superficial cortex. Their subjects were schizophrenic patients who were taking medication and control subjects at rest and during verbal and spatial tasks that were designed to explore hemispheric asymmetries in processing. The authors concluded that patients and control subjects did not differ at rest, but differences emerged with cognitive activation such that in patients the verbal task induced symmetric increases in blood flow and the spatial task induced greater left hemispheric increases, whereas in control subjects changes were compatible with hemispheric specializations. When sex differences were examined, schizophrenic women showed minimal changes that were greatest when performing the verbal task and not the spatial task as in other groups.Some of these results are open to question because group differences all

REFERENCES

Gur RE, Skolnick BE, Gur RC, Caroff S, Rieger W, Obrist WD, Younkin D, Reivich M:  Brain functions in psychiatric disorders: Regional cerebral blood flow in medicated schizophrenics . Arch Gen Psychiatry 1983;;40:1250-1254.
Sheppard G, Gruzelier J, Manchanda R, Hirsch SR, Wise R, Frackowiak R, Jones T:  15o Positron emission tomographic scanning in predominantly never-treated acute schizophrenic patients . Lancet 1983;;2:1448-1452.
Duffy G:  Activation , in Greenfield NS, Sternbach RA (eds): Handbook of Psychophysiology . New York, Holt, Rinehart & Winston, 1972;, p 572.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Gur RE, Skolnick BE, Gur RC, Caroff S, Rieger W, Obrist WD, Younkin D, Reivich M:  Brain functions in psychiatric disorders: Regional cerebral blood flow in medicated schizophrenics . Arch Gen Psychiatry 1983;;40:1250-1254.
Sheppard G, Gruzelier J, Manchanda R, Hirsch SR, Wise R, Frackowiak R, Jones T:  15o Positron emission tomographic scanning in predominantly never-treated acute schizophrenic patients . Lancet 1983;;2:1448-1452.
Duffy G:  Activation , in Greenfield NS, Sternbach RA (eds): Handbook of Psychophysiology . New York, Holt, Rinehart & Winston, 1972;, p 572.

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