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Validity of RDC and DSM-III-Reply

James F. Leckman, MD; Myrna M. Weissman, PhD; Brigitte A. Prusoff, PhD; Keith A. Caruso; Kathleen R. Merikangas, PhD; David L. Pauls, PhD; Kenneth K. Kidd, PhD
Arch Gen Psychiatry. 1985;42(6):634-634. doi:10.1001/archpsyc.1985.01790290116016
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In Reply.—  Zimmerman and Coryell have suggested that by not "faithfully" applying the diagnostic criteria for melancholia (DSM-III) and for endogenous depression (RDC) in our recent family study of depressive subtypes,1 we cannot validly assess these competing diagnostic systems. We disagree. They correctly point out that the diagnostic algorithms we used to generate these subtype diagnoses were not exactly identical to those of the DSM-III and RDC. As we indicated in the "Subjects and Methods" section of our report, subtype assignments were based on the proband's or relative's response to specific queries during a direct interview using a modified version of the Schedule for Affective Disorder and Schizophrenia. The modifications included questions about depressive symptoms that were not included in the original schedule, such as earlymorning awakening, lack of reactivity, and morning worsening. As a result, most, but not all, of the specific criteria for the melancholic and endogenous subtypes were

REFERENCES

Leckman JF, Weissman MM, Prusoff BA, Caruso KA, Merikangas KR, Pauls DL, Kidd KK:  Subtypes of depression: A family study perspective . Arch Gen Psychiatry 1984;;41:833-838.
Leckman JF, Sholomskas D, Thompson WD, Belanger A, Weissman MM:  Best estimate of lifetime psychiatric diagnosis: A methodologic study . Arch Gen Psychiatry 1982;;39:879-883.
Leckman JF, Weissman MM, Merikangas KR, Pauls DL, Prusoff BA:  Panic disorder and major depression: Increased risk of depression, alcoholism, panic, and phobic disorders in families of depressed probands with panic disorder . Arch Gen Psychiatry 1983;;40:1055-1066.
Leckman JF, Caruso KA, Prusoff BA, Weissman MM, Merikangas KR, Pauls DL:  Appetite disturbance and excessive guilt in major depression . Arch Gen Psychiatry 1984;;41:839-844.
Weissman MM, Prusoff BA, Merikangas KR:  Is delusional depression related to bipolar disorder? Am J Psychiatry 1984;;141:892-893.
Weissman MM, Wickramarantne P, Merikangas KR, Leckman JF, Prusoff BA, Caruso KA, Kidd KK, Gammon GD:  Onset of major depression in early adulthood: Increased familial loading and specificity . Arch Gen Psychiatry 1984;;41:1136-1143.

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Leckman JF, Weissman MM, Prusoff BA, Caruso KA, Merikangas KR, Pauls DL, Kidd KK:  Subtypes of depression: A family study perspective . Arch Gen Psychiatry 1984;;41:833-838.
Leckman JF, Sholomskas D, Thompson WD, Belanger A, Weissman MM:  Best estimate of lifetime psychiatric diagnosis: A methodologic study . Arch Gen Psychiatry 1982;;39:879-883.
Leckman JF, Weissman MM, Merikangas KR, Pauls DL, Prusoff BA:  Panic disorder and major depression: Increased risk of depression, alcoholism, panic, and phobic disorders in families of depressed probands with panic disorder . Arch Gen Psychiatry 1983;;40:1055-1066.
Leckman JF, Caruso KA, Prusoff BA, Weissman MM, Merikangas KR, Pauls DL:  Appetite disturbance and excessive guilt in major depression . Arch Gen Psychiatry 1984;;41:839-844.
Weissman MM, Prusoff BA, Merikangas KR:  Is delusional depression related to bipolar disorder? Am J Psychiatry 1984;;141:892-893.
Weissman MM, Wickramarantne P, Merikangas KR, Leckman JF, Prusoff BA, Caruso KA, Kidd KK, Gammon GD:  Onset of major depression in early adulthood: Increased familial loading and specificity . Arch Gen Psychiatry 1984;;41:1136-1143.

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