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Stimulant Therapy of 'Adult Hyperactivity'

Paul H. Wender, MD; Fred W. Reimherr, MD; David R. Wood, MD
Arch Gen Psychiatry. 1985;42(8):840-840. doi:10.1001/archpsyc.1985.01790310108018
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To the Editor.—  Mattes et al1 published data that suggested that stimulant medication is ineffective in relieving the symptoms of attention deficit disorder, residual type (ADDRT, or "adult hyperactivity"). Their findings are in striking contrast with our findings using methylphenidate,2 pemoline,3 pargyline,4 and deprenyl,5 and a replication with methylphenidate.6 An examination of the article by Mattes et al1 and a personal communication offer a possible explanation to account for their apparent failure to replicate our findings. Their subjects differed from ours in an important aspect: their scores on the Parents' Rating Scale (PRS), which is a measure of childhood hyperactivity. In their study, the mean scores for ADD with hyperactivity and ADD without hyperactivity were 10.7 and 6.7, respectively; in contrast, we found that only subjects with scores of 12 or higher (the 95th percentile or higher) showed a therapeutic response. Only seven

REFERENCES

Mattes JA, Boswell L, Oliver H:  Methylphenidate effects on symptoms of attention deficit disorder in adults . Arch Gen Psychiatry 1984;;41:1059-1063.
Wood DR, Reimherr FW, Wender PH:  Diagnoses and treatment of minimal brain dysfunction in adults . Arch Gen Psychiatry 1976;;33:1453-1460.
Wender PH, Reimherr FW, Wood DR:  Attention deficit disorder ('minimal brain dysfunction') in adults . Arch Gen Psychiatry 1981;;38:449-456.
Wender PH, Wood DR, Reimherr FW, Ward M:  An open trial of pargyline in the treatment of attention deficit disorder, residual type . Psychiatry Res 1983;;9:329-336.
Wood DR, Reimherr FW, Wender PH:  The use of l-deprenyl in the treatment of attention deficit disorder, residual type . Psychopharmacol Bull 1983;;19:627-629.
Wender PH, Reimherr FW, Wood DR, et al:  A controlled study of methylphenidate in the treatment of attention deficit disorder, residual type . Am J Psychiatry , in press.

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Mattes JA, Boswell L, Oliver H:  Methylphenidate effects on symptoms of attention deficit disorder in adults . Arch Gen Psychiatry 1984;;41:1059-1063.
Wood DR, Reimherr FW, Wender PH:  Diagnoses and treatment of minimal brain dysfunction in adults . Arch Gen Psychiatry 1976;;33:1453-1460.
Wender PH, Reimherr FW, Wood DR:  Attention deficit disorder ('minimal brain dysfunction') in adults . Arch Gen Psychiatry 1981;;38:449-456.
Wender PH, Wood DR, Reimherr FW, Ward M:  An open trial of pargyline in the treatment of attention deficit disorder, residual type . Psychiatry Res 1983;;9:329-336.
Wood DR, Reimherr FW, Wender PH:  The use of l-deprenyl in the treatment of attention deficit disorder, residual type . Psychopharmacol Bull 1983;;19:627-629.
Wender PH, Reimherr FW, Wood DR, et al:  A controlled study of methylphenidate in the treatment of attention deficit disorder, residual type . Am J Psychiatry , in press.

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