To the Editor.— In the March 1987 issue of the Archives, Jaeckle et al1 reported their findings confirming that the adrenal sensitivity to exogenous corticotropin (ACTH) was enhanced in patients with major depressive disorder. Based on their findings, they further suggested that this adrenal abnormality might be related pathophysiologically to the resistance of cortisol secretion to dexamethasone suppression. We want to contest both their confirmation and suggestion, as the article contains several questionable statements.A major problem was the use of an intravenous bolus of a supraphysiological dose of ACTH α1-24 (cosyntropin) to test the adrenal sensitivity. In our previous studies,2 the dose of cosyntropin to mimic a maximum physiologically stimulated ACTH level, such as that seen during insulin hypoglycemia in normal subjects, was on the order of 0.02 to 0.05 μg/kg. A dose of 250 μg of cosyntropin is 60 to 70 times that in an
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
Instructions
Comments are moderated and will appear on the site at the discretion of the Archives of General Psychiatry editors. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest* Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Customize your page view by dragging & repositioning the boxes below.
and access these and other features:
Register Now
Enter your username and email address. We'll send you a reminder to the email address on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.