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The Effect of Diagnostic Hierarchy in Genetic Epidemiological Studies of Psychiatric Disorders-Reply

Priya Wickramaratne, PhD; Myrna M. Weissman, PhD
Arch Gen Psychiatry. 1994;51(11):927-927. doi:10.1001/archpsyc.1994.03950110087012
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In reply  We welcome this opportunity to further clarify the concepts underlying the method that was used in our article1 to compute the risks for late-onset MD. There appears to be some confusion regarding our definition of late-onset MD. In this article1 as well as in our previous publications on this topic,2,3 we have defined late-onset MD as cases in which the first onset of MD occurs after age 30 years. In other words, the event of interest is that an individual remains free of MD until age 30, and then his or her first episode of MD develops after age 30. The rationale for this definition is that we are hypothesizing that individuals who have a first onset of MD after age 30 have a different form of the disorder from individuals who have a first onset of MD before age 30. Any recurrent episode of MD occurring before

REFERENCES

Weissman MM, Wickramaratne PJ, Adams PB, Lish JD, Horwath E, Charney D, Woods SW, Leeman E, Frosch E.  The relationship between panic disorder and major depression: a new family study . Arch Gen Psychiatry . 1993;;50:767-780.
Weissman MM, Wickramaratne PJ, Merikangas KR, Leckman JF, Prusoff BA, Caruso KA, Kidd KK, Gammon GD.  Onset of major depression in early adulthood: increased familial loading and specificity . Arch Gen Psychiatry . 1984;;41:1136-1143.
Wickramaratne PJ, Prusoff BA, Merikangas KR, Weissman MM.  The use of survival time models with nonproportional hazard functions to investigate age of onset in family studies . J Chronic Dis . 1986;;39:389-397.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Weissman MM, Wickramaratne PJ, Adams PB, Lish JD, Horwath E, Charney D, Woods SW, Leeman E, Frosch E.  The relationship between panic disorder and major depression: a new family study . Arch Gen Psychiatry . 1993;;50:767-780.
Weissman MM, Wickramaratne PJ, Merikangas KR, Leckman JF, Prusoff BA, Caruso KA, Kidd KK, Gammon GD.  Onset of major depression in early adulthood: increased familial loading and specificity . Arch Gen Psychiatry . 1984;;41:1136-1143.
Wickramaratne PJ, Prusoff BA, Merikangas KR, Weissman MM.  The use of survival time models with nonproportional hazard functions to investigate age of onset in family studies . J Chronic Dis . 1986;;39:389-397.

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