0
February 1995, Vol 52, No. 2 >
Article | February 1995

Developmental Brain Abnormalities in Schizophrenia: Contributions of Genetic and Perinatal Factors

Antonio Vita, MD; Emilio Sacchetti, MD
Arch Gen Psychiatry. 1995;52(2):157-157. doi:10.1001/archpsyc.1995.03950140075013
Text Size: A A A
Published online
Article
References
Comments

In the progress of their pivotal work on individuals from the Copenhagen Schizophrenia High-risk Project, Cannon et al1 found linearly increasing measures of the cerebral ventricular system to be a function of the level of genetic risk for schizophrenia and the presence of obstetric complications (OCs) in the offspring of normal and schizophrenic parents. They discuss these results as being suggestive of the "neurodevelopmental nature of brain abnormalities in schizophrenia."

However, whether results obtained in a cohort of mainly nonschizophrenic subjects may be transferred tout court to schizophrenia is not obvious.

The controversial literature on the association between family history (FH) of schizophrenia and ventricular size in schizophrenia is more compatible with an inverse rather than a direct relationship between the two variables.2,3

Further, twin studies recognize a genetic control of ventricular size but indicate also a disease effect, with the schizophrenic twins showing consistently larger ventricles than

REFERENCES

1 +
Cannon TD, Mednick SA, Parnas J, Schulsinger F, Praestholm J, Vestergaard A.  Developmental brain abnormalities in the offspring of schizophrenic mothers, I: contributions of genetic and perinatal factors . Arch Gen Psychiatry . 1993;;50:551-564.
2 +
Murray RM, Reveley AM, Lewis SW.  Family history, obstetric complications and cerebral abnormality in schizophrenia . In: Tsuang MT, Simpson JC, eds. Handbook of Schizophrenia: Nosology, Epidemiology and Genetics . New York, NY: Elsevier Science Publishing Co Inc; 1988;;3:563-577.
3 +
Vita A, Deici M, Giobbio GM, Garbarini M, Morganti C, Braga M, Internizzi G.  A reconsideration of the relationship between cerebral structrual adnormalities and family history of schizophrenia . Psychiatry Res . 1994;;53:41-55.
4 +
Suddath RL, Christison GW, Torrey EF, Casanova MF, Weinberger DR.  Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia . N Engl J Med . 1990;;332:789-794.
5 +
Reddy R, Mukherjee S, Schnur DB, Chin J, Degreef G.  History of obstetric complications, family history, and CT scan findings in schizophrenic patients . Schizophr Res . 1990;;3:311-314.
6 +
Lewis SW, Murray RM.  Obstetric complications, neurodevelopmental deviance and risk of schizophrenia . J Psychiatr Res . 1987;;21:413-422.

First Page Preview

First page PDF preview

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Cannon TD, Mednick SA, Parnas J, Schulsinger F, Praestholm J, Vestergaard A.  Developmental brain abnormalities in the offspring of schizophrenic mothers, I: contributions of genetic and perinatal factors . Arch Gen Psychiatry . 1993;;50:551-564.
2 +
Murray RM, Reveley AM, Lewis SW.  Family history, obstetric complications and cerebral abnormality in schizophrenia . In: Tsuang MT, Simpson JC, eds. Handbook of Schizophrenia: Nosology, Epidemiology and Genetics . New York, NY: Elsevier Science Publishing Co Inc; 1988;;3:563-577.
3 +
Vita A, Deici M, Giobbio GM, Garbarini M, Morganti C, Braga M, Internizzi G.  A reconsideration of the relationship between cerebral structrual adnormalities and family history of schizophrenia . Psychiatry Res . 1994;;53:41-55.
4 +
Suddath RL, Christison GW, Torrey EF, Casanova MF, Weinberger DR.  Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia . N Engl J Med . 1990;;332:789-794.
5 +
Reddy R, Mukherjee S, Schnur DB, Chin J, Degreef G.  History of obstetric complications, family history, and CT scan findings in schizophrenic patients . Schizophr Res . 1990;;3:311-314.
6 +
Lewis SW, Murray RM.  Obstetric complications, neurodevelopmental deviance and risk of schizophrenia . J Psychiatr Res . 1987;;21:413-422.

Correspondence

Submit a Letter
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2012 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems