RT Journal
A1 Kumar A, Kepe V, Barrio JR, et al
T1 PRotein binding in patients with late-life depression
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 2011
FD November 1
VO 68
IS 11
SP 1143
OP 1150
DO 10.1001/archgenpsychiatry.2011.122
UL http://dx.doi.org/10.1001/archgenpsychiatry.2011.122
AB Context 
                  Depression has been identified as a risk factor and a prodrome of dementia. Common neurobiological mechanisms may underlie this clinical and phenomenologic overlap.Objective 
                  To examine and compare protein (amyloid and tau) binding in critical brain regions in patients diagnosed as having late-life major depressive disorder (MDD) and healthy control individuals using 2-(1-{6-[(2-[18F]fluoroethyl)(methyl)-amino]-2-naphthyl}ethylidene) malononitrile ([18F]FDDNP) positron emission tomography.Design 
                  A cross-section neuroimaging study using positron emission tomography.Setting 
                  University of California, Los Angeles.Patients 
                  Our samples comprised 20 patients diagnosed as having MDD and 19 healthy control individuals of comparable age, sex, and educational level.Main Outcome Measure 
                  Relative distribution volume in regions of interest was used as the measure of [18F]FDDNP binding in all study participants.Results 
                  When compared with controls, [18F]FDDNP binding was significantly higher overall and in the posterior cingulate and lateral temporal regions in the MDD group.Conclusions 
                  These findings suggest that neuronal injury associated with higher protein load in critical brain regions might provide a mechanism in the pathophysiologic manifestation of MDD in late life and have implications for the therapeutics of depression in elderly individuals.