RT Journal
A1 Carli V, Sarchiapone M, Camardese G, Romano L, DeRisio S
T1 MIrtazapine in the treatment of panic disorder
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 2002
FD July 1
VO 59
IS 7
SP 661
OP 662
DO 10.1001/archpsyc.59.7.661
UL http://dx.doi.org/10.1001/archpsyc.59.7.661
AB 
Mirtazapine has been reported to target symptoms of anxiety (agitation,
somatization, psychic anxiety, panic attacks) that often occur in depressed
patients.1- 3
Enhancement of both noradrenergic and serotonergic transmission through α
autoreceptor and α-heteroreceptor antagonism, respectively, coupled
with the blockade of 5-HT2 and 5-HT3 receptors, has
been considered the main mechanism of this apparent pharmacological efficacy
for anxiety symptoms.3- 4
Additionally, H1 receptor antagonism facilitates an initial soporific
effect.