RT Journal
A1 Wassink TH, Epping EA, Rudd D, et al
T1 INfluence of znf804a on brain structure volumes and symptom severity in individuals with schizophrenia
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 2012
FD September 1
VO 69
IS 9
SP 885
OP 892
DO 10.1001/archgenpsychiatry.2011.2116
UL http://dx.doi.org/10.1001/archgenpsychiatry.2011.2116
AB Context 
                  The single-nucleotide polymorphism rs1344706 in the gene ZNF804a has been associated with schizophrenia and with quantitative phenotypic features, including brain structure volume and the core symptoms of schizophrenia.Objective 
                  To evaluate associations of rs1344706 with brain structure and the core symptoms of schizophrenia.Design 
                  Case-control analysis of covariance.Setting 
                  University-based research hospital.Participants 
                  Volunteer sample of 335 individuals with schizophrenia spectrum disorders (306 with core schizophrenia) and 198 healthy volunteers.Main Outcome Measures 
                  Cerebral cortical gray matter and white matter (WM) volumes (total and frontal, parietal, temporal, and occipital lobes), lateral ventricular cerebrospinal fluid volume, and symptom severity from the Scale for the Assessment of Negative Symptoms and the Scale for the Assessment of Positive Symptoms divided into 3 domains: psychotic, negative, and disorganized.Results 
                  The rs1344706 genotype produced significant main effects on total, frontal, and parietal lobe WM volumes (F = 3.98, P = .02; F = 4.95, P = .007; and F = 3.08, P = .05, respectively). In the schizophrenia group, rs1344706 produced significant simple effects on total (F = 3.93, P = .02) and frontal WM volumes (F = 7.16, P < .001) and on psychotic symptom severity (F = 6.07, P = .003); the pattern of effects was concordant with risk allele carriers having larger volumes and more severe symptoms of disease than nonrisk homozygotes. In the healthy volunteer group, risk allele homozygotes had increased total WM volume compared with nonrisk allele carriers (F = 4.61, P = .03), replicating a previously reported association.Conclusions 
                  A growing body of evidence suggests that the risk allele of rs1347706 is associated with a distinctive set of phenotypic features in healthy volunteers and individuals with schizophrenia. Our study supports this assertion by finding that specific genotypes of the polymorphism are associated with brain structure volumes in individuals with schizophrenia and healthy volunteers and with symptom severity in schizophrenia.