RT Journal
A1 Hoeft F, Gabrieli JE, Whitfield-Gabrieli S, et al
T1 FUnctional brain basis of hypnotizability
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 2012
FD October 1
VO 69
IS 10
SP 1064
OP 1072
DO 10.1001/archgenpsychiatry.2011.2190
UL http://dx.doi.org/10.1001/archgenpsychiatry.2011.2190
AB Context 
                  Focused hypnotic concentration is a model for brain control over sensation and behavior. Pain and anxiety can be effectively alleviated by hypnotic suggestion, which modulates activity in brain regions associated with focused attention, but the specific neural network underlying this phenomenon is not known.Objective 
                  To investigate the brain basis of hypnotizability.Design 
                  Cross-sectional, in vivo neuroimaging study performed from November 2005 through July 2006.Setting 
                  Academic medical center at Stanford University School of Medicine.Patients 
                  Twelve adults with high and 12 adults with low hypnotizability.Main Outcome Measures 
                  Functional magnetic resonance imaging to measure functional connectivity networks at rest, including default-mode, salience, and executive-control networks; structural T1 magnetic resonance imaging to measure regional gray and white matter volumes; and diffusion tensor imaging to measure white matter microstructural integrity.Results 
                  High compared with low hypnotizable individuals had greater functional connectivity between the left dorsolateral prefrontal cortex, an executive-control region of the brain, and the salience network composed of the dorsal anterior cingulate cortex, anterior insula, amygdala, and ventral striatum, involved in detecting, integrating, and filtering relevant somatic, autonomic, and emotional information using independent component analysis. Seed-based analysis confirmed elevated functional coupling between the dorsal anterior cingulate cortex and the dorsolateral prefrontal cortex in high compared with low hypnotizable individuals. These functional differences were not due to any variation in brain structure in these regions, including regional gray and white matter volumes and white matter microstructure.Conclusions 
                  Our results provide novel evidence that altered functional connectivity in the dorsolateral prefrontal cortex and dorsal anterior cingulate cortex may underlie hypnotizability. Future studies focusing on how these functional networks change and interact during hypnosis are warranted.