RT Journal
A1 Kirov G, Owen MJ, Jones I, McCandless F, Craddock N
T1 TRyptophan hydroxylase gene and manic-depressive illness
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 1999
FD January 1
VO 56
IS 1
SP 98
OP 99
DO 10.1001/archpsyc.56.1.98
UL http://dx.doi.org/10.1001/archpsyc.56.1.98
AB 
We read with interest the article on a positive association between a polymorphism in the tryptophan hydroxylase (TPH) gene and manic-depressive illness.1 The authors found a significantly increased rate of the "A" allele in patients compared with control subjects (52% vs 36%).1 The TPH gene encodes for the rate-limiting enzyme of serotonin synthesis, making it a strong candidate gene for manic-depressive disorder; therefore, we attempted to replicate these results.