RT Journal A1 Severus W, Ahrens BB, Stoll AL T1 OMega-3 fatty acids—the missing link? JF Archives of General Psychiatry JO Archives of General Psychiatry YR 1999 FD April 1 VO 56 IS 4 SP 380 OP 381 DO 10.1001/archpsyc.56.4.380 UL http://dx.doi.org/10.1001/archpsyc.56.4.380 AB In numerous studies, including prospective cohort studies,2 case-control studies,3 and intervention trials4—omega-3 fatty acids have been shown to reduce the risk of primary cardiac arrest/sudden cardiac death, presumably owing to their antiarrhythmic properties. A prospective double-blind, placebo-controlled trial of omega-3 fatty acids observed a notable reduction of moderate to low-grade ventricular premature complexes in patients with frequent ventricular arrhythmias.5 Furthermore, a high arachidonic acid (omega-6)–docosahexaenoic acid ratio (omega-3) has been reported in the heart muscle of men who died of sudden cardiac death, compared with accidents.6