RT Journal
A1 Dursun SM, McIntosh D, Milliken H
T1 CLozapine plus lamotrigine in treatment-resistant schizophrenia
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 1999
FD October 1
VO 56
IS 10
SP 950
OP 950
DO 10.1001/archpsyc.56.10.950
UL http://dx.doi.org/10.1001/archpsyc.56.10.950
AB 
Glutamate is an excitatory neurotransmitter, and clozapine acts as a glutamate antagonist. Lamotrigine, an anticonvulsant and mood stabilizer, inhibits excessive release of glutamate.2 Both drugs block the psychotomimetic effects of phencyclidine (PCP). These schizophrenia-like symptoms are attributed to PCP's activity at the NMDA (glutamate) receptor. The biochemical significance of these glutamate interactions in schizophrenia remains unclear and is hotly debated. There is evidence to suggest that there is abnormal glutamatergic binding in the areas of the brain associated with psychotic symptoms in patients with schizophrenia.3