RT Journal
A1 Quitkin FM, Klein DF
T1 WHat conditions are necessary to assess antidepressant efficacy?
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 2000
FD April 1
VO 57
IS 4
SP 323
OP 324
DO 10.1001/archpsyc.57.4.323
UL http://dx.doi.org/10.1001/archpsyc.57.4.323
AB 
We believe that these data can appropriately assess morbidity but do not adequately assess efficacy. The only data available were pretreatment and posttreatment mean total Hamilton Depression Rating scores, most without SEs. Although constrained by database inadequacies, effect size estimates were calculated and Khan et al report that "nearly half the studies had less than medium effect size (<0.5)."