RT Journal
A1 Paulus MP, Tapert SF, Schuckit MA
T1 NEural activation patterns of methamphetamine-dependent subjects during decision making predict relapse
JF Archives of General Psychiatry
JO Archives of General Psychiatry
YR 2005
FD July 1
VO 62
IS 7
SP 761
OP 768
DO 10.1001/archpsyc.62.7.761
UL http://dx.doi.org/10.1001/archpsyc.62.7.761
AB Context 
    Relapse is a common clinical problem in individuals with substance dependence. Previous studies have implicated a multifactorial process underlying relapse; however, the contribution of specific neural substrates has not yet been examined.Objective 
    To determine whether results from functional magnetic resonance imaging (fMRI) shortly after drug cessation could predict relapse in stimulant-dependent individuals.Participants and Design 
    Treatment-seeking methamphetamine-dependent males (N = 46) underwent fMRI 3 to 4 weeks after cessation of drug use. Of the 40 subjects who were followed up a median of 370 days, 18 relapsed and 22 did not.Main Outcome Measure 
    Blood oxygen level–dependent fMRI activation during a simple 2-choice prediction task.Results 
    The fMRI activation patterns in right insular, posterior cingulate, and temporal cortex obtained early in recovery correctly predicted 20 of 22 subjects who did not relapse and 17 of 18 subjects who did. A Cox regression analysis revealed that the combination of right middle frontal gyrus, middle temporal gyrus, and posterior cingulate activation best predicted the time to relapse.Conclusion 
    To our knowledge, this is the first investigation to show that fMRI can be used to predict relapse in substance-dependent individuals.